Antibody detailed product information

Code No. K0204-3 プリントPrint out
Anti-Txnip (VDUP1) mAb
Price ¥30,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Sep 23, 2019 in JST)
Clonality Monoclonal
Clone JY1
Isotype
(Immunized Animal)
Mouse IgG2b
Applications WB 10 μg/mL  
IP 2 μg/200 μL of cell extract from 5x106 cells  
Immunogen
(Antigen)
Recombinant Human Txnip/VDUP1
Reactivity [Gene ID]

Human[10628], Mouse[56338], Rat*[117514](20709139)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names thioredoxin interacting protein, THIF, HHCPA78, EST01027/THIF, Tbp-2, Hyplip1, AA682105, 1200008J08Rik
Background Thioredoxin (TRX)-binding protein (Txnip), also called Vitamin D3 up-regulated protein 1 (VDUP1) is an endogenous inhibitor of TRX. Redox-dependent regulation of Txnip by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of Txnip to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX. It has been reported that Txnip plays important roles in diverse cellular processes, including the regulation of cellular redox balance, apoptosis, proliferation, and differentiation.
Related products K0205-3 Anti-Txnip (VDUP1) mAb
M013-3 Anti-Thioredoxin (Trx-tag) mAb
Product category Research area:Cellular stress
Data


Citations
  1. Yu Y et al. Overexpression of thioredoxin-binding protein 2 increases oxidation sensitivity and apoptosis in human lens epithelial cells. Free Radic Biol Med. 57, 92-104 (2013)(PMID:23291592)

Western Blotting

  1. Yoshioka J et al. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ. Res. 101, 1328-1338 (2007)(PMID:17916779)
  2. Nivet-Antoine Y et al. trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion. Biochimie. 92, 1766-71 (2010)(PMID:20709139)
  • The availability is based on the information in Japan at 00:05, Sep 23, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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