Antibody detailed product information

Code No. K0142-6 プリントPrint out
Anti-PSMA (Human) mAb-Biotin
Price ¥20,000
Size 50 µg/50 µL
Availability (in Japan) 1-9
(In Japan at 00:05, Aug 25, 2019 in JST)
Clonality Monoclonal
Clone 107-1A4
Isotype
(Immunized Animal)
Mouse IgG1
Applications FCM 3-5 µg/mL (final concentration)  
ELISA Can be used.  
Immunogen
(Antigen)
LNCaP cell homogenate
Reactivity [Gene ID]

Human[2346]

Storage buffer 1 mg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names FOLH1, folate hydrolase (prostate-specific membrane antigen) 1
Background

PSMA is a type II transmembrane protein expressed at high levels in prostate cancer and in tumor-associated neovasculature. PSMA is also known as a glutamate carboxypeptidase II (EC 3.4.17.21) that hydrolyzes the neuropeptide, N-acetyl-L-aspartyl-L-glutamate, releasing glutamate, the dominant excitatory neurotransmitter/neuromodulator of the mammalian central nervous system. The ability of PSMA to liberate g-glutamate may allow the removal of glutamate residues from dietary folates, which are unable to be transported into cells in their poly-g-glutamate form. Overexpression of PSMA in prostate cancer cells may represent an advantageous adaptation that allows the uptake of folates required for rapid division. The exopeptidase activity exhibited by PSMA and its high-level overexpression in prostate cancer cells make it a potential target for selective anticancer therapy and prodrug activation.

Related products K0142-3 Anti-PSMA (Human) mAb
K0142-4 Anti-PSMA (Human) mAb-FITC
K0142-5 Anti-PSMA (Human) mAb-PE
Product category Research area:Cancer Cell surface antigens Exosomes
Data


References
  1. Brown LG et al. A novel monoclonal antibody 107-1A4 with high prostate specificity: generation, characterization of antigen expression, and targeting of human prostate cancer xenografts. Prostate Cancer Prostatic Dis. 1, 208-215 (1998)(PMID: 12496897
  2. Wang S et al. Identification of prostate specific membrane antigen (PSMA) as the target of monoclonal antibody 107-1A4 by proteinchip; array, surface-enhanced laser desorption/ionization (SELDI) technology. Int J Cancer 15, 871-876 (2001)(PMID: 11351309
  3. Kawakami K et al. Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer. BMC Cancer 17, 316 (2017)(PMID: 28476099
  • The availability is based on the information in Japan at 00:05, Aug 25, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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