Antibody detailed product information

Code No. K0142-3 プリントPrint out
Anti-PSMA (Human) mAb
Price ¥30,000
Size 100 µg/100 µL
Availability (in Japan) 1-9
(In Japan at 00:05, Sep 18, 2019 in JST)
Clonality Monoclonal
Clone 107-1A4
Isotype
(Immunized Animal)
Mouse IgG1
Applications FCM 10 µg/mL (final concentration)  
Other(Exosome isolation) reported.  (PMID: 28476099)
Immunogen
(Antigen)
LNCaP cell homogenate
Reactivity [Gene ID]

Human[2346]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names FOLH1, folate hydrolase (prostate-specific membrane antigen) 1, PSM, FGCP, FOLH, GCP2, mGCP, GCPII, NAALAD1, NAALAdase
Background PSMA is a type II transmembrane protein expressed at high levels in prostate cancer and in tumor-associated neovasculature. PSMA is also known as a glutamate carboxypeptidase II (EC 3.4.17.21) that hydrolyzes the neuropeptide, N-acetyl-L-aspartyl-L-glutamate, releasing glutamate, the dominant excitatory neurotransmitter/neuromodulator of the mammalian central nervous system. The ability of PSMA to liberate g-glutamate may allow the removal of glutamate residues from dietary folates, which are unable to be transported into cells in their poly-g-glutamate form. Overexpression of PSMA in prostate cancer cells may represent an advantageous adaptation that allows the uptake of folates required for rapid division. The exopeptidase activity exhibited by PSMA and its high-level overexpression in prostate cancer cells make it a potential target for selective anticancer therapy and prodrug activation.
Related products K0142-4 Anti-PSMA (Human) mAb-FITC
K0142-5 Anti-PSMA (Human) mAb-PE
K0142-6 Anti-PSMA (Human) mAb-Biotin
Product category Research area:Cancer Cell surface antigens Exosomes
Data

Citations

Other(Exosome isolation)

  1. Kawakami K et al. Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer. BMC Cancer 17, 316 (2017)(PMID:28476099)
  • The availability is based on the information in Japan at 00:05, Sep 18, 2019 in JST.
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  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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