Antibody detailed product information

Code No. D373-3 プリントPrint out
Anti-MELK (Human) mAb
Price ¥48,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Aug 19, 2019 in JST)
Clonality Monoclonal
Clone 11-28
Isotype
(Immunized Animal)
Mouse IgG1 κ
Applications WB 1 µg/mL  
IH 1-5 µg/mL (Heat treatment is necessary for paraffin-embedded sections.)  
Immunogen
(Antigen)
Recombinant protein, corresponding to amino acids 264-601 of human MELK
Reactivity [Gene ID]

Human[9833]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names maternal embryonic leucine zipper kinase, hPK38, HPK38, pEg3 kinase
Background MELK is a member of the AMPK serine/threonine kinase family. It is involved in mammalian embryonic development. Overexpression of MELK protein is also reported in various types of human cancer. MELK plays critical roles not only in cancer cell growth but also in formation or maintenance of cancer stem cells that have the ability to self-renew and differentiate. Emerging evidence indicates that cancer stem cells are resistant to chemotherapy and radiation therapy and are associated with cancer relapse. For these reasons, MELK is considered a promising drug target molecule for cancer treatment.
Product category Research area:Stem cell research Cancer
Data


Citations

Immunohistochemistry

  1. Chung S et al. Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor. Oncotarget 7, 18171-82 (2016)(PMID:26918358)
References
  1. Chung S et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget 3, 1629-40 (2012)(PMID: 23283305
  • The availability is based on the information in Japan at 00:05, Aug 19, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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