Antibody detailed product information

Code No.	D363-3
Anti-Ly6k (Mouse) mAb
Price	¥52,800
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 17:33, Apr 26, 2024 in JST）
Clonality	Monoclonal
Clone	mk34
Isotype (Immunized Animal)	Rat IgG2aκ
Applications	WB　1 μg/mL IP　15 μg/sample FCM　1 μg/mL IH*　reported. （PMID: 20920470 / 27005865）
Immunogen (Antigen)	Mouse testicular water-insoluble fraction
Reactivity [Gene ID]	Human, Mouse[76486], Rat
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	mLy-6K, lymphocyte antigen 6 complex, locus K
Background	Ly6k（lymphocyte antigen 6 complex, locus K）は主に精巣で発現しているGPIアンカー型タンパク質です。同じくGPIアンカー型タンパク質であるTex101（Testis expressed gene 101）と複合体を形成することが知られています。Tex101またはLy6kをそれぞれ欠損させた精子は、形態や運動性の面では正常であり、体外受精は可能ですが、生体内においては子宮から卵管に移行することができず不妊となることから、Tex101/Ly6k複合体は精子の受精能獲得に重要な働きをしていると考えられています。
Related products	D357-3 Anti-Ace (CD143) (Mouse) mAb M207-3 Anti-MitoPLD (Pld6) mAb PM044 Anti-PIWIL2 (MILI) (Mouse) pAb D365-3 Anti-PIWIL2 (MILI) (Mouse) mAb
Product category	Research area:Stem cell research Cancer
Data
References	Endo S et al. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci Rep. 6, 23616 (2016)（PMID: 27005865） Maruyama M et al. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun. 402, 75-81 (2010)（PMID: 20920470） Yoshitake H et al. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem Biophys Res Commun. 372, 277-82 (2008)（PMID: 18503752） Tsukamoto H et al. Testicular proteins associated with the germ cell-marker, TEX101: involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis. Biochem Biophys Res Commun. 345, 229-38 (2006)（PMID: 16678124）

The availability is based on the information in Japan at 17:33, Apr 26, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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