Antibody detailed product information

Code No. D281-6 プリントPrint out
Anti-CD61 (GPIIIa) (Human) mAb-Biotin
Price ¥36,000
Size 50 µg/50 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Aug 19, 2019 in JST)
Clonality Monoclonal
Clone T74
Isotype
(Immunized Animal)
Mouse IgG1 κ
Applications FCM 1 µg/mL (final concentration)  
ELISA Can be used.  
Immunogen
(Antigen)
Human thrombocyte
Reactivity [Gene ID]

Human[3690]

Storage buffer 1 mg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C
Conjugate Biotin
Manufacturer MBL
Alternative names ITGB3, integrin subunit beta 3, GP3A
Background Glycoprotein IIIa, a β3 (CD61) subunit of integrin αIIbβ3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human β3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or αvβ3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmann’s thrombasthenia.
Related products D281-3 Anti-CD61 (GPIIIa) (Human) mAb
Product category Research area:Immunology Cell surface antigens Exosomes
Data




References
  1. Kunicki TJ et al. Inheritance of the human platelet alloantigen, PlA1, in type I Glanzmann's thrombasthenia. J Clin Invest. 67, 717-24 (1981)(PMID: 7193688
  2. Zimrin AB et al. Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. J Clin Invest. 81, 1470-5 (1988)(PMID: 2452834
  3. Prandini MH et al. Isolation of the human platelet glycoprotein IIb gene and characterization of the 5' flanking region. Biochem Biophys Res Commun. 156, 595-601 (1988)(PMID: 2845986
  4. Katagiri Y et al. Involvement of alpha v beta 3 integrin in mediating fibrin gel retraction. J Biol Chem. 270, 1785-90 (1995)(PMID: 7530248
  • The availability is based on the information in Japan at 00:05, Aug 19, 2019 in JST.
  • The special price is shown in red color.
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  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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