Antibody detailed product information

Code No.	BMP064
Anti-SLC22A12 (URAT1) (Human) pAb
Price	¥66,000
Size	50 µL
Availability (in Japan)	1-9 （In Japan at 00:05, Apr 25, 2024 in JST）
Clonality	Polyclonal
Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	FCM　1:1,000 IC　1:1,000 IH　1:5,000 (Heat treatment is necessary for paraffin embedded sections.）
Immunogen (Antigen)	Human SLC22A12-derived synthetic peptide
Reactivity [Gene ID]	Human[116085]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	RST, OAT4L
Background	SLC22A12, also known as urate transporter 1 (URAT1), is a member of the organic cation/anion/zwitterion transporter family. This transporter is present on the epithelial cells of proximal tubules in the renal cortex and mediates urate uptake. Gene mutations or functional defects of URAT1 have been identified in patients with renal hypouricemia, which is characterized by low serum urate levels. Disorders associated with this condition include uric acid urolithiasis; hematuria; hypercalcemia; or occasionally, exercise-induced acute renal failure.
Related products	BMP064 Anti-SLC22A12 (URAT1) (Human) pAb PM035 Normal Rabbit IgG
Data
Citations	Immunohistochemistry Tojo A et al. The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with κ light chain deposition. Med Mol Morphol. 49, 48-52 (2016)(PMID:26141649) Uemura N et al. Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains. Neurosci Lett. 659, 99-103 (2017)(PMID:28870626)

The availability is based on the information in Japan at 00:05, Apr 25, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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