Antibody detailed product information

Code No.	BMP011
Anti-SLC7A5 (LAT1) (Human) pAb
Price	¥66,000
Size	100 µL
Availability (in Japan)	10 or more （In Japan at 00:05, Apr 19, 2024 in JST）
Clonality	Polyclonal
Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	WB　1:1,000 IH　1:1,000 (Heat treatment is necessary for paraffin embedded sections.)
Immunogen (Antigen)	Human SLC7A5-derived synthetic peptide
Reactivity [Gene ID]	Human[8140]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	solute carrier family 7 (amino acid transporter light chain, L system) member 5, E16, CD98, 4F2LC, MPE16
Background	SLC7A5, L-type amino acid transporter 1 (LAT1), forms as a heterodimeric complex with the heavy chain of the cell surface antigen 4F2 (4F2hc/CD98). It transports neutral amino acids, most of which are essential amino acids across blood brain barrier. L-dopa, which is commonly used to treat Parkinson’s disease, also enters the brain the LAT1/CD98 complex. In addition, tumors with increased expression of SLC7A5 have been reported. Increased uptake of amino acids through SLC7A5 may facilitate tumor cell growth and survival.
Related products	BMP040 Anti-SLC7A3 (CAT3) (Human) pAb BMP011 Anti-SLC7A5 (LAT1) (Human) pAb BMP041 Anti-SLC7A8 (LAT2) (Human) pAb
Product category	Research area:Cancer
Data
Citations	Western Blotting Barel M et al. Francisella tularensis regulates the expression of the amino acid transporter SLC1A5 in infected THP-1 human monocytes. Cell Microbiol. 14, 1769-83 (2012)(PMID:22804921)

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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