Antibody detailed product information
| Code No. | 566-H | |
| Anti-CD117 (c-Kit) (Human) pAb | ||
| Price | ¥32,000 | |
| Size | 6 mL | |
| Availability (in Japan) | 0 (Contact us) （In Japan at 00:05, Apr 20, 2024 in JST） |
|
| Clonality | Polyclonal | |
| Clone | Polyclonal | |
| Isotype (Immunized Animal) |
Rabbit IgG | |
| Applications | IC Ready for use. IH Ready for use. |
|
| Immunogen (Antigen) |
Carrier protein conjugated synthetic peptide (C-terminal of c-kit gene product (K963)) | |
| Reactivity [Gene ID] | Human[3815] |
|
| Storage buffer | 20 mM HEPES/1% BSA/0.135 M NaCl/0.1% NaN3 | |
| Storage temp. | 4°C | |
| Conjugate | Unlabeled | |
| Manufacturer | MBL | |
| Alternative names | KIT, PBT, SCFR | |
| Background | c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development. | |
| Related products | 566 Anti-CD117 (c-Kit) (Human) pAb PM035 Normal Rabbit IgG |
|
| Product category | Research area:Stem cell research Cell surface antigens | |
| Data |  |
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- The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
- The special price is shown in red color.
- Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
- Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization - For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
- For storage temparature: RT: room temparature
- Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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