Anti-STAU1 (Human) pAb

Price

¥66,000

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

200 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation RNP Immunoprecipitation
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	WB 1:1,000 IP 1.5 μL/50 μL of cell extract from 1.25 x 10⁶ cells RIP 15 μg/500 μL of cell extract from 1.5 x 10⁷ cells
Immunogen (Antigen)	KLH-conjugated synthetic peptide MKLGKKPMYKPVDPYSRMQ （82-100 aa)
Reactivity [Gene ID]	Human[6780](PMID: 22584570), Mouse(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	staufen double-stranded RNA binding protein 1, STAU
Background	Mammalian Staufen1 (Stau1) is a ubiquitous double-stranded RNA binding protein associated with polysomes. It has two protein isoforms, molecular weights of 55 and 63 kDa. The 55 kDa isoform associates with 40S and 60S ribosomal subunit and colocalizes with the rough endoplasmic reticulum. Stau1 is thought to function in transporting mRNA, controlling and eliciting mRNA decay. Previous study showed that the Stau1 recruits upf1 to 3' UTR region of Arf1 mRNA and induces the Stau1-mediated mRNA decay (SMD). Recent study suggests that Stau1 regulates diverse class of mammalian transcripts. In order to identify mRNA targets of Staufen proteins, RIP-Assay technology was employed and identified distinct but overlapping subset of cellular mRNAs associated with Stau1 and Stau2-containing ribonucleoprotein complexes.
Related products	RN1001 RIP-Assay Kit RN1005 RIP-Assay Kit for microRNA RN013P Anti-STAU2 (Human) pAb RN016P Anti-FMR1 pAb
Citations	Western Blotting Hosono Y et al. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell 171, 1559-1572 (2017)(PMID:29245011) Immunoprecipitation Hosono Y et al. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell 171, 1559-1572 (2017)(PMID:29245011) RNP Immunoprecipitation Ramen AV et al. Selenoprotein W expression and regulation in mouse brain and neurons. Brain Behav. 3, 562-74 (2013)(PMID:24392277) Yu Z et al. Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. J Biol Chem. 287, 22560-72 (2012)(PMID:22584570)
Product category	Research area RNA-RNP Network Neuroscience Brands RiboCluster Profiler™

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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