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HOME > Product search results > Code No. PM066 Anti-p62 C-terminal pAb

Code No. PM066

Anti-p62 C-terminal pAb

Price

¥38,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Sep 15, 2019 in JST)

Size

100 µL

Data
  • Western Blotting

  • Immunoprecipitation

  • Immunocytochemistry

  • Immunohistochemistry

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Guinea pig Ig (aff.)
Applications
WB
1:1,000  
IP
5 µL/300 µL of cell extract from 3x106 cells  
IC
1:500  
IH
1:100  
Immunogen (Antigen) Human p62 C-terminal peptide
Reactivity [Gene ID]

Human[8878], Mouse[18412], Rat[113894], Hamster[100768352]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names SQSTM1, sequestosome 1, p62
Background p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain. This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency.
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Citations

Western Blotting

  1. Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238)
  2. De Pace R et al. Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome. PLoS Genet. 14, e1007363 (2018)(PMID:29698489)
  3. Qian Q et al. Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity. Cell Mol Gastroenterol Hepatol. 8, 95-110 (2019)(PMID:30926581)

Immunocytochemistry

  1. Matsumoto G et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 8, 9585 (2018)(PMID:29941919)

Immunohistochemistry

  1. Kimura H et al. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2, e89462 (2017)(PMID:28097232)
  2. Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238)
Product category
Research area
Autophagy
Brands
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  • The availability is based on the information in Japan at 17:00, Sep 15, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.