This site is for customers in Japan. Customers in other regions, please go to Global page.
HOME > Product search results > Code No. M221-3 Anti-WAPL (Human) mAb

Code No. M221-3

Anti-WAPL (Human) mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 01:30,
Aug 22, 2017 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunoprecipitation

Clonality Monoclonal Clone C11-10
Isotype (Immunized Animal) Mouse IgG2a
Applications
WB
1 μg/mL  
IP
5 μg/sample  
Immunogen (Antigen) Human WAPL, recombinant protein
Reactivity [Gene ID]

Human[23063], Mouse(-), Rat(-), Monkey

Storage buffer 1 mg/mL in 10 mM phosphate buffer (pH 7.4) containing 150 mM NaCl and 50% Glycerol (pH 7.2)
 
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names WAPAL, Wings apart-like protein homolog, Friend of EBNA2 protein, FOE, KIAA0261
Background WAPL is a human homologue of wings apart-like protein (wapl) first identified in Drosophila. WAPL, also known as Friend of EBNA2 protein, regulates heterochromatin structure through formimg a complex with precocious dissociation of sisters protein 5 (Pds5) to promote cohesin release from chromatin. WAPL is highly expressed in cervical dysplasia and carcinoma induced by HPV E6 and E7 oncoproteins.
Related products K0090-3 Anti-Securin (Pds-1) mAb
K0201-3 Anti-Separase mAb
K0202-3 Anti-Cohesin (Rad21/Scc1) mAb
D348-3 Anti-Pfetin (Human) mAb
PM078 Anti-Hemoglobin F (Human) pAb
M222-3 Anti-WAPL (Human) mAb
References
  1. Oikawa K et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 64, 3545-3549 (2004) (PMID:15150110)
  2. Gandhi R et al. Human Wapl Is a Cohesin-Binding Protein that Promotes Sister-Chromatid Resolution in Mitotic Prophase. Curr Biol. 16, 2406-2417 (2006) (PMID:17112726)
  3. Kueng S et al. Wapl Controls the Dynamic Association of Cohesin with Chromatin.Cell 127, 955–967 (2006) PMID:17113138
  4. Ohbayashi T et al. Unscheduled overexpression of human WAPL promotes chromosomal instability.BBRC 11, 699-704 (2007) PMID:17382297
  5. Kuroda M et al. The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target. Br J Cancer. 92, 290-293 (2005) PMID:15655544
Product category
Research area
Cancer
Brands
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Aug 22, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.