Price
¥48,000
Availability (in Japan)
10 or more
(In Japan at 17:00,
Mar 29, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | R32-44 | ||
Isotype (Immunized Animal) | Rat IgG2cκ | ||||
Applications |
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Immunogen (Antigen) | Recombinant protein, corresponding to amino acids 590-713 of mouse Np95 (Uhrf1) | ||||
Reactivity [Gene ID] | |||||
Storage buffer | PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | ICBP90, RNF106, AL022808 | ||||
Background | DNA methylation inheritance is the process of copying pre-existing methylation patterns onto newly replicated DNA strand after DNA replication. Dnmt1 is the maintenance DNA methyltransferase, which methylates hemimethylated CpGs that appear after DNA repairs and replications. The mouse Np95, also known as Uhrf1, is a nuclear protein, which contains an ubiquitin-like domain, a tandem Tudor domain, a PHD (Plant Homeodomain) finger, an SRA (SET-and RING-associated) domain, and a RING (Really Interesting New Gene) finger domain. Np95 recognizes hemimethylated CpGs via the SRA domain, and recruits Dnmt1 to the sites to transfer the methylation patterns onto the newly synthesized DNA strand. Therefore, the interaction between Np95 and Dnmt1 is necessary for the inheritance of DNA methylation. | ||||
Related products | D289-3 Anti-Np95 (Uhrf1) (Mouse) mAb MH-12-3 Anti-PCNA (Proliferating Cell Nuclear Antigen) mAb MK-15-3 Anti-Rb (Human) mAb PM044 Anti-PIWIL2 (MILI) (Mouse) pAb M209-3 Anti-GST-tag mAb M207-3 Anti-MitoPLD (Pld6) mAb PM085 Anti-ZBTB24 pAb PM086 Anti-ZBTB24 (Human) pAb D346-3 Anti-5-methylcytidine (m5C) mAb |
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