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HOME > Product search results > Code No. D308-3 Anti-HB-EGF (Human) mAb

Code No. D308-3

Anti-HB-EGF (Human) mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Sep 15, 2019 in JST)

Size

100 µg/100µL

Data
  • Western Blotting

  • Immunoprecipitation

  • Flow Cytometry

  • Immunocytochemistry

Clonality Monoclonal Clone 3H4
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 µg/mL  
IP
0.1 µg/100 µL of cell extract from 6x105 cells  
FCM
5 µg/mL (final concentration)  
IC
1 µg/mL  
Immunogen (Antigen) Human HB-EGF, extracellular domain
Reactivity [Gene ID]

Human[1839], Mouse(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names proheparin-binding EGF-like growth factor, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor
Background Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family that bind to and activate the EGF receptor (EGFR/ErbB1) and ErbB4. HB-EGF is synthesized as a single pass membrane-anchored precursor containing a heparin-binding domain, EGF domain, and cytoplasmic domain and then released in the soluble form by ectodomain shedding. HB-EGF is necessary for normal development of the lung, eyelid, and heart and also plays important roles in the development and progression of cancer, such as in cancer metastasis and angiogenesis, and drug-resistance.
Related products M220-3 Anti-HB-EGF mAb
MI-12-1 Anti-EGF-R (Human) mAb
References
  1. Hamaoka M et al. Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding. J Biochem. 148, 55069 (2010)(PMID: 20332144
Product category
Research area
Cancer
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  • The availability is based on the information in Japan at 17:00, Sep 15, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.