Anti-MORC3 mAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 25, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Monoclonal	Clone	17A9
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1-5 µg/mL IC 5 µg/mL
Immunogen (Antigen)	Recombinant Human MORC3
Reactivity [Gene ID]	Human[23515], Mouse[338467], Rat[304074]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	NXP2, ZCW5, ZCWCC3
Background	MORC3 {microrchidia (MORC) family CW-type zinc finger 3, KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conserved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al. reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.
Related products	M041-3 Anti-PML (Human) mAb
Citations	Immunoprecipitation Ceribelli A et al. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 14, R97 (2012)(PMID:22546500) Immunofluorescence Takahashi K et al. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18, 1701-9 (2007)(PMID:17332504) Mimura Y et al. Two-step colocalization of MORC3 with PML nuclear bodies. J Cell Sci. 123, 2014-24 (2010)(PMID:20501696)
Product category	Research area Cancer

The availability is based on the information in Japan at 00:05, Apr 25, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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