Price
¥48,000
Availability (in Japan)
10 or more
(In Japan at 00:05,
Mar 29, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | 2422 | ||
Isotype (Immunized Animal) | Hamster IgG | ||||
Applications | |||||
Immunogen (Antigen) | thioglycollate-elicited mouse peritoneal macrophages | ||||
Reactivity [Gene ID] | Mouse[17304] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | P47, MP47, Mfgm, SED1, lactadherin | ||||
Background | Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted glycoprotein from thioglycollate-elicited macrophages and bind to phosphatidylserine exposed on the cell surface of apoptotic cells, then bind strongly to cells expressing anb3 integrin via its RGD (arginine-glycine-aspartate) motif. Thus, MFG-E8 is an important protein to mediate the engulfment of apoptotic cells by activated macrophages. | ||||
Related products | M199-3 Armenian Hamster IgG (isotype control) D199-3 Anti-MFG-E8 (Mouse) mAb SY-001 Anti-Fas (CD95) (Human) mAb |
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Citations |
Western Blotting
Neutralization
Immunoprecipitation
Flow Cytometry
Immunohistochemistry
ELISA
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Product category |
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