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HOME > Product search results > Code No. RN123PW Anti-YTHDF2 pAb

Code No. RN123PW

Anti-YTHDF2 pAb

Price

¥48,000

Availability (in Japan)

1-9

(In Japan at 17:00,
Sep 22, 2019 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunoprecipitation

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:1,000  
IP
5 µL/500 µL of cell extract from 5 x 106 cells/sample  
IC*
reported.  (PMID: 30065315
Reactivity [Gene ID]

Human[51441], Mouse[213541], Rat(w)[313953], Hamster[100763174]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names CAHL, HGRG8, NY-REN-2
Background N(6)-methyladenosine (m6A) is one of the most abundant modified nucleosides found in some viral RNA and eukaryotic RNA including mRNA, tRNA, rRNA and lncRNA. It has been reported that m6A modification is involved in the regulation of mRNA export, stability and translation. YTH N(6)-methyladenosine RNA binding protein 2 (YTHDF2), functioning as m6A reader protein, is involved in methylation-dependent RNA degradation. YTHDF2 selectively binds to m6A-containing RNA through its C-terminal domain and its N-terminal domain is required for localization of the protein-m6A-containing RNA complex to P-body.
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Citations

Western Blotting

  1. Li M et al. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 19, 69 (2018)(PMID:29855337)
  2. Li Z et al. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. (2018) In press.(PMID:30065315)

Immunocytochemistry

  1. Li Z et al. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. (2018) In press.(PMID:30065315)
Product category
Research area
RNA-RNP Network
Epigenetics
Cancer
Brands
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  • The availability is based on the information in Japan at 17:00, Sep 22, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.