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HOME > Product search results > Code No. PM098 Anti-Inosine pAb

Code No. PM098

Anti-Inosine pAb

Price

¥60,000

Availability (in Japan)

10 or more

(In Japan at 01:30,
May 28, 2017 in JST)

Size

100 µL

Related information

Data
  • Immunoprecipitation

  • Immunoprecipitation

  • Immunocytochemistry

  • Immunohistochemistry

Clonality Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
IP
10 µL/sample  
IC
1:100-1:200  
IH**
Can be used.  
ELISA
Can be used.  
DB
Can be used.  
Immunogen (Antigen) Carrier protein-conjugated Inosine
Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Ino, I
Background Adenosine-to-inosine (A-to-I)  RNA editing, the most common modification that occurs in mammalian mRNAs and ncRNAs, is the conversion of adenosine to inosine catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family. Because inosine has a similar chemical structure to guanosine, it pairs preferentially with cytidine. This influences the regulation of splicing, stabilization, and translation. A-to-I RNA editing also affects miRNA biogenesis and their recognition by target mRNAs. A malfunction in the editing mechanism results in various human diseases such as neurological disorders and cancers.
Related products D347-3 Anti-Pseudouridine mAb
D345-3 Anti-1-methyladenosine (m1A) mAb
D346-3 Anti-5-methylcytidine (m5C) mAb
PM077 Anti-5-hydroxymethylcytosine (5hmC) pAb
MI-11-3 Anti-Bromodeoxyuridine mAb
MI-11-5 Anti-Bromodeoxyuridine mAb-PE
M218-3 Anti-5-hydroxymethylcytosine (5hmC) mAb
RN019M Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb
RN131P Anti-N6-methyladenosine (m6A) pAb
RN016M Anti-7-methylguanosine (m7G)-Cap mAb
RN017M Anti-7-methylguanosine (m7G) mAb
References
  1. Morse DP, Bass BL. Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry 36, 8429-34 (1997)(PMID: 9264612
  2. Zinshteyn B, Nishikura K. Adenosine-to-inosine RNA editing. Wiley Interdiscip Rev Syst Biol Med. 1, 202-9 (2009)(PMID: 20835992
  3. Nigita G et al. A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules. Front Bioeng Biotechonol. 3, 37 (2015)(PMID: 25859542
  4. Nishikura K. A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol. 17, 83-96 (2016)(PMID: 26648264
Product category
Research area
RNA-RNP Network
Epigenetics
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, May 28, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.