Anti-IL-33 (Mouse) mAb

Price

¥52,800

Availability (in Japan)

1-9

（In Japan at 00:05,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation
Clonality	Monoclonal	Clone	4G4
Isotype (Immunized Animal)	Mouse IgG2aκ
Applications	WB 1 µg/mL IP 2 µg/sample
Immunogen (Antigen)	Recombinant protein corresponding to amino acid residues 109-266 of mouse IL-33
Reactivity [Gene ID]	Human(-), Mouse[77125], Rat(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	interleukin 33, Il33
Background	The Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, has important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1a/b and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
Related products	M138-3 Anti-IL-33 (Human) mAb M187-3 Anti-IL-33 (Mouse) mAb (Functional Grade) M188-3 Anti-IL-33 (Mouse) mAb (Functional Grade) PM033 Anti-IL-33 (Human) pAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Citations	Western Blotting Ohno T et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol. 183, 7890-7 (2009)(PMID:19933859)
Product category	Research area Immunology Cytokine & Growth Factors

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.