Anti-UVRAG mAb

Price

¥52,800

Availability (in Japan)

1-9

（In Japan at 17:00,
Apr 25, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Monoclonal	Clone	1H4
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 µg/mL IC* reported. （PMID: 22310240） IP* reported. （PMID: 25086043 / 26387534 / 28872463）
Immunogen (Antigen)	Recombinant Human UVRAG (389-699 a.a.)
Reactivity [Gene ID]	Human[7405], Mouse[78610], Rat[308846], Hamster[100751375]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	UV radiation resistance associated; p63, DHTX, VPS38
Background	Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. UVRAG (UV irradiation resistance-associated gene) has been identified as an essential component of the Beclin 1-PI3KC3 complex that suppresses tumorigenicity of human colon and promotes Beclin 1 dependent autophagy.
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Citations	Western Blotting Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761) Fulcher LJ et al. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 6, 160255 (2016)(PMID:27784791) Cheng Z et al. Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem. 292, 2065-2079 (2017)(PMID:27994061) Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463) Immunoprecipitation Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761) Zhong Y et al. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 289, 26021-37 (2014)(PMID:25086043) Nemazanyy I et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 6, 8283 (2015)(PMID:26387534) Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463) Immunocytochemistry Huang W et al. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 22, 473-49 (2012)(PMID:22310240)
Product category	Research area Autophagy Apoptosis

The availability is based on the information in Japan at 17:00, Apr 25, 2024 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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