This site is for customers in Japan. Customers in other regions, please go to Global page.
HOME > Product search results > Code No. M137-3 Anti-HMGB1 (HMG1) mAb

Code No. M137-3

Anti-HMGB1 (HMG1) mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 00:05,
Sep 17, 2019 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 4C9
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
1 µg/mL  
IF*
reported.  (PMID: 23860260
Immunogen (Antigen) Human HMGB1 internal region synthetic peptide
Reactivity [Gene ID]

Human[3146], Mouse[15289], Rat[25459]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names SBP-1
Background High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein, and extensively modified posttranslationally, by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100% amino acid sequence homology between rat and mouse, and 99% homology between rodent and human. Intracellular HMGB1 has been studied previously for its roles in binding DNA; stabilizing nucleosome formation; as a general transcription factor for nucleolar and mitochondrial RNA polymerases; and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 is recently implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.
Related products D075-3 Anti-HMGB1 (HMG1) mAb
PD017 Anti-Beclin 1 pAb
Citations

Immunofluorescence

  1. Szénási T et al. Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis. Biochim Biophs Acta 1829, 1075-91 (2013)(PMID:23860260)
Product category
Research area
Epigenetics
Cancer
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Sep 17, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.