Anti-CD11c (Mouse) mAb

Price

¥30,800

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Immunoprecipitation Flow Cytometry
Clonality	Monoclonal	Clone	223H7
Isotype (Immunized Animal)	Rat IgG2a
Applications	IP 5 µg/1000 µL of cell extract from 5x10⁶ cells FCM 5-10 µg/mL (final concentration) IH* reported. （PMID: 20042501 / 24695531 / 24752483）
Immunogen (Antigen)	C57BL/6 Mice-derived dendritic cells
Reactivity [Gene ID]	Mouse[16411]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	Itgax, integrin apha X
Background	The CD11c (alpha X integrin; ~150 kDa) glycoprotein non-covalently associates with CD18 (beta2 integrin; ~95 kDa) to form the heterodimeric complement receptor type 4 (CR4), which is involved in monocyte/granulocyte adhesion during inflammatory responses. The CD11c/CD18 receptor binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c/CD18 is also implicated in B cell proliferation and mediates B cell binding to fibrinogen. CD11c is commonly used as a marker for dendritic cells, but it is also expressed on macrophages, monocytes, granulocytes, NK cells, activated T and B lymphocytes and microglia.
Related products	M100-4 Anti-CD11c (Mouse) mAb-FITC M100-6 Anti-CD11c (Mouse) mAb-Biotin
Citations	Flow Cytometry Crawford JR et al. FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation. J Leukoc Biol. 92, 699-711 (2012)(PMID:22493081) Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531) Immunohistochemistry Ferreira CS et al. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). J Virol. 84, 3033-42 (2010)(PMID:20042501) Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531) Catani JP et al.Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma. Transl Oncol. 9, 565-574 (2016)(PMID:24752483)
Product category	Research area Immunology Cell surface antigens

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.