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HOME > Product search results > Code No. D356-3 Anti-Jmjd1c (Mouse) mAb

Code No. D356-3

Anti-Jmjd1c (Mouse) mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 01:30,
Sep 22, 2017 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunohistochemistry

Clonality Monoclonal Clone 13B
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 µg/mL  
IH
5 µg/mL  
Reactivity [Gene ID]

Mouse[108829]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names jumonji domain containing 1C, Jmjdic, TRIP8
Background マウスJumonjiファミリー分子の一つであるJmjd1cは2種類のバリアントが存在し、一つはExon1と2から転写されるLong valiant (282 kDa)であり、もう一つはExon1Bから転写されるShort valiant (261 kDa)である。Jmjd1cはほぼすべての臓器に発現しているが、精巣だけでこの2種類のバリアントが見られることから精巣で特徴的な発現を示す。Jmjd1c-/-マウスでは加齢に伴い未分化精原細胞数の著しい減少とアポトーシスの増加が確認された。Jmjd1cは雄の減数分裂の生殖細胞の細胞死を抑制して精子形成の維持に必須であることが示唆されている。  またJmjCドメインを持つJumonjiファミリー分子の中で、Jmjd1a,Jmjd1bはヒストン脱メチル化活性を持つことが報告されているが、Jmjd1cは活性中心のアミノ酸配列が異なることから、ヒストン以外のタンパク質をターゲットとしていると報告されている。
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References
  1. Kuroki S et al. JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. Biol. Reprod. 89, 93 (2013) (PMID:24006281)
Product category
Research area
Stem cell research
Epigenetics
Cancer
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Sep 22, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.