Anti-HB-EGF (Human) mAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Data	Western Blotting Immunoprecipitation Flow Cytometry Immunocytochemistry
Clonality	Monoclonal	Clone	3H4
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 µg/mL IP 0.1 µg/100 µL of cell extract from 6x10⁵ cells FCM 5 µg/mL (final concentration) IC 1 µg/mL
Immunogen (Antigen)	Human HB-EGF, extracellular domain
Reactivity [Gene ID]	Human[1839], Mouse(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	proheparin-binding EGF-like growth factor, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor
Background	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family that bind to and activate the EGF receptor (EGFR/ErbB1) and ErbB4. HB-EGF is synthesized as a single pass membrane-anchored precursor containing a heparin-binding domain, EGF domain, and cytoplasmic domain and then released in the soluble form by ectodomain shedding. HB-EGF is necessary for normal development of the lung, eyelid, and heart and also plays important roles in the development and progression of cancer, such as in cancer metastasis and angiogenesis, and drug-resistance.
Related products	M220-3 Anti-HB-EGF mAb MI-12-1 Anti-EGF-R (Human) mAb
References	Hamaoka M et al. Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding. J Biochem. 148, 55069 (2010)（PMID: 20332144）
Product category	Research area Cancer

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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