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HOME > Product search results > Code No. B-MU703UC Anti-MLH1 mAb

Code No. B-MU703UC

Anti-MLH1 mAb

Price

¥158,400

Availability (in Japan)

0
(Contact us)

(In Japan at 00:05,
Aug 25, 2019 in JST)

Size

1 mL

Data
  • Immunohistochemistry

    Colon tissue stained with Anti-MLH 1 using Dab chromogen

Clonality Monoclonal Clone ES05
Isotype (Immunized Animal) Mouse IgG1
Applications
IH
  
Reactivity [Gene ID]

Human

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate Unlabeled Manufacturer BIOGENEX LABORATORIES,INC
Background MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2. MSH6 and PMS2. During DNA replication, strand misalignment can occure resulting in alterations to microsatellirte repeats, often referred to as microsattelite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in tumors with MSI, such as some forms of colon cancer e.g. Hereditary nonpolyposis colon cancer (HNPCC), a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, Gastric carcinoma and ovarian carcinoma.
Related products B-AM7035M Anti-MLH1 mAb
B-AN8445ME Anti-PMS2 mAb
B-NU844UCE Anti-PMS2 mAb
Product category
Tools
Molecular pathology tools
Brands
BioGenex
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  • The availability is based on the information in Japan at 00:05, Aug 25, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.