Anti-CD117 (c-Kit) (Human) pAb

Price

¥63,800

Availability (in Japan)

1-9

（In Japan at 00:05,
Apr 17, 2024 in JST）

Size

100 µL

Citations

Data Sheet

SDS

Data	Western Blotting Immunocytochemistry Immunohistochemistry
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit IgG
Applications	WB 1:1,000 IC 1:200 (Heat treatment is necessary for paraffin embedded sections.) IH 1:200 (Heat treatment is necessary for paraffin embedded sections.)
Immunogen (Antigen)	Carrier protein conjugated synthetic peptide (C-terminal of c-kit gene product (K963))
Reactivity [Gene ID]	Human[3815]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	KIT proto-oncogene receptor tyrosine kinase
Background	c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
Related products	566-H Anti-CD117 (c-Kit) (Human) pAb
Citations	Immunohistochemistry Sakurai S et al. Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal. Am J Pathol. 154, 23-8 (1999)(PMID:9916914) Lyford GL et al. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 51, 496-501 (2002)(PMID:12235070) Wilczynski SP et al. Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. Hum Pathol. 36, 242-249 (2005)(PMID:15791568) Koch AC et al. Does the expression of c-kit (CD117) in neuroendocrine tumors represent a target for therapy? Ann N Y Acad Sci. 1073, 517-26 (2006)(PMID:17102120) Enomoto T et al. Urgent surgery for intraperitoneal bleeding from GIST during imatinib therapy. Clin J Gasteroenterol. 3, 73-7 (2010)(PMID:26189998) Funasaka K et al. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration. Transl Oncol. 13, 100848 (2020)(PMID:32818739)
Product category	Research area Stem cell research Cancer Cell surface antigens

The availability is based on the information in Japan at 00:05, Apr 17, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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