抗体製品詳細情報

Code No.	RN019P
Anti-HNRNPK pAb
価格(税別)	¥66,000
包装	200 µL (1 mg/mL)
在庫	1-9 （2024/04/26 00:05時点）
クローナリティー	Polyclonal
クローン	Polyclonal
アイソタイプ (免疫動物)	Rabbit Ig (aff.)
使用法	WB　1 µg/mL IP　5 µg/500 µL of cell extract from 5 x 10⁶ cells IC*　reported. （PMID: 24990929 / 26990993） RIP　15 µg/500 µL of cell extract from 1.5 x 10⁷ cells Other(eCLIP)　reported. （PMID: 27018577）
免疫原(抗原)	KLH conjugated synthetic peptide, corresponding to C-terminus of human HNRNPK
交差性 [Gene ID]	Human[3190], Mouse[15387], Rat[117282]
性状	1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度	-20°C
標識	Unlabeled
メーカー	MBL
別称	heterogeneous nuclear ribonucleoprotein K, RP11-575L7.1, CSBP, HNRPK, TUNP
背景	The heterogeneous nuclear ribonucleoprotein K (hnRNP K), is an RNA-binding protein containing 3 KH RNA-binding domains. It binds to both RNA and DNA and is a component of the hnRNP complex. hnRNP K is associated with pre-mRNA and appears to influence the processing of pre-mRNAs and metabolism of mRNA. hnRNP K is predominantly localized at the nucleus and shuttles between the nucleus and the cytoplasm. Therefore, hnRNP K is thought to be involved in the transport of mRNA. Phosphorylation of hnRNP K leads to its cytoplasmic accumulation and is important for cell migration and metastasis. In the cytoplasm, hnRNP K functions as a translational regulator of specific mRNAs such as c-myc mRNA, 16L2 mRNA, and r15-LOX mRNA. Further, it specifically associates with c-src kinase, leading to c-src activation and hnRNP K phosphorylation, which affect the binding of hnRNP K to RNA.
関連製品	RN1001 RIP-Assay Kit RN1005 RIP-Assay Kit for microRNA RN052PW Anti-HNRNPC pAb RN060PW Anti-HNRNPD (AUF1) pAb RN011P Anti-PTBP1 (Human) pAb RN024P Anti-PCBP1 pAb RN025P Anti-PCBP2 pAb RN114PW Anti-HNRNPA1 pAb
製品カテゴリー	分野:RNA-RNPネットワークブランド:RiboCluster Profiler™
データ
使用文献	Western Blotting Folci A et al. Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons. J Neurosci. 34, 9088-95 (2014)(PMID:24990929) Chung BM et al. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.　J Cell Biol. 208, 613-27 (2015)(PMID:25713416) Immunoprecipitation Chung BM et al. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.　J Cell Biol. 208, 613-27 (2015)(PMID:25713416) Immunocytochemistry Folci A et al. Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons. J Neurosci. 34, 9088-95 (2014)(PMID:24990929) Chung BM et al. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.　J Cell Biol. 208, 613-27 (2015)(PMID:25713416) Sundararaman B et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 61, 903-13 (2016)(PMID:26990993) RNP Immunoprecipitation Chung BM et al. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.　J Cell Biol. 208, 613-27 (2015)(PMID:25713416) Lubelsky Y, Ulitsky I. Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells. Nature 555, 107-111 (2018)(PMID:29466324) Other(eCLIP) Van Nostrand EL et al. Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP). Nat Methods. 13, 508-14 (2016)(PMID:27018577)

※在庫につきましては2024年04月26日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
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※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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