抗体 製品詳細情報

Code No. PM033
Anti-IL-33 (Human) pAb
価格(税別) ¥52,800
包装 100 µL
在庫 10以上
（2024/04/26 17:33時点）
クローナリティー Polyclonal
クローン Polyclonal
アイソタイプ
(免疫動物)		 Rabbit Ig (aff.)
使用法 WB　1:500  
IC*　reported.  （PMID: 22460292）
IH　1:500-1:1,000 (Heat treatment is necessary for paraffin embedded sections.)  
IF*　reported.  （PMID: 33098728）
免疫原(抗原) Recombinant Human full length IL-33 (270 a.a.)
交差性 [Gene ID]

Human[90865]
性状 PBS/50% glycerol, pH 7.2
保存温度 -20°C
標識 Unlabeled
メーカー MBL
背景 Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, have important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
関連製品 M161-3 Anti-IL-33 (Mouse) mAb
D358-3 Anti-IL-38 (IL1F10) (Human) mAb
D359-3 Anti-IL-38 (IL1F10) (Human) mAb
製品カテゴリー 分野:免疫 サイトカイン・増殖因子
データ

使用文献

Western Blotting

  1. Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292)

Immunocytochemistry

  1. Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292)

Immunohistochemistry

  1. Matsuda A et al. The role of interleukin-33 in chronic allergic conjunctivitis. Invest Ophthalmol Vis Sci. 50, 4646-52 (2009)(PMID:19458329)
  2. Guo Z et al. IL-33 promotes airway remodeling and is a marker of asthma disease severity. J Asthma. 51, 863-9 (2014)(PMID:24796648)
  3. Abe K et al. Interleukin-33/ST2-Mediated Inflammation Plays a Critical Role in the Pathogenesis and Severity of Type I Autoimmune Hepatitis. Hepatol Commun. 3, 670-684 (2019)(PMID:31061955)
  4. Nagaoka S et al. The blockade of interleukin-33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma. Cancer Sci. 112, 347-358 (2021) (PMID:33098728)

Immunofluorescence

  1. Nagaoka S et al. The blockade of interleukin-33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma. Cancer Sci. 112, 347-358 (2021) (PMID:33098728)

※在庫につきましては2024年04月26日 17時33分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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