抗体 製品詳細情報

Code No. M021-3
Anti-Neuropsin (Mouse) mAb
価格(税別) ¥52,800
包装 100 µL (1 mg/mL)
在庫 10以上
（2024/04/26 17:33時点）
クローナリティー Monoclonal
クローン MabB5
アイソタイプ
(免疫動物)		 Rat IgG2a
使用法 WB　1-5 µg/mL  
IP　2 µg/sample  
IC*　reported.  （PMID: 11854276）
IH*　reported.  （PMID: 9620300）
Function*　reported.  （PMID: 27327541）
NT*　reported.  （PMID: 12944500 / 16308352）
免疫原(抗原) Recombinant
交差性 [Gene ID]

Mouse[259277]
性状 1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C
標識 Unlabeled
メーカー MBL
別称 Klk8, Kallikrein 8, kallikrein related-peptidase 8
背景 Neuropsin is a trypsin-type, extracellular, serine protease that was first cloned from mouse limbic brain as a factor related to neural plasticity. Physiological studies indicated that kindling stimulation induced neuropsin mRNA and its protease activity also increased in limbic areas during kindling and long-term potentiation. Subsequent study indicated that neuropsin mRNA localized not only in the limbic brain, but also in developing organs and adult keratinocytes. Recent immunohistochemical analysis demonstrated that neuropsin localized exclusively in the keratinizing epithelia of the epidermis and various stratified mucous membranes. During development, neuropsin was found in the various epithelia at embryonic days 14.5-15.5, prior to formation of the stratum corneum. Much stronger expression of neuropsin is observed in nude mouse skin and mucous membranes than in normal mice. Those studies suggested that neuropsin is related to differentiation of keratinocytes and the process of keratogenesis.
製品カテゴリー 分野:神経科学
データ


使用文献
  1. Momota Y et al. Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy. Eur J Neurosci. 10, 760-4 (1998)(PMID:9749739)

Western Blotting

  1. Shimizu C et al. Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem. 273, 11189-96 (1998)(PMID:9556608)

Neutralization

  1. Matsumoto-Miyai K et al. NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci. 23, 7727-36 (2003)(PMID:12944500)
  2. Tamura H et al. Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol. 570, 541-51 (2006)(PMID:16308352)

Immunoprecipitation

  1. Shimizu C et al. Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem. 273, 11189-96 (1998)(PMID:9556608)
  2. Kato K et al. Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain. J Biol Chem. 276, 14562-71 (2001)(PMID:11278732)

Immunocytochemistry

  1. Oka T et al. Role of loop structures of neuropsin in the activity of serine protease and regulated secretion. J Biol Chem. 277, 14724-30 (2002)(PMID:11854276)

Immunohistochemistry

  1. Inoue N et al. Expression of neuropsin in the keratinizing epithelial tissue-immunohistochemical analysis of wild-type and nude mice. J Invest Dermatol. 110, 923-31 (1998)(PMID:9620300)

Function

  1. Herring A et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 12, 1273-1287 (2016)(PMID:27327541)

※在庫につきましては2024年04月26日 17時33分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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