抗体 製品詳細情報

Code No. D146-3 プリントプリント
Anti-Nectin-1 (Mouse) mAb
価格(税別) ¥40,000
包装 100 µg/100 µL
在庫 10以上
(2019/09/22 00:05時点)
クローナリティー Monoclonal
クローン 48-12
アイソタイプ
(免疫動物)
Rat IgG2a
使用法 WB* (PMID: 24587018)
IC 20 μg/mL  
IH* (PMID: 24587018 / 26663531)
免疫原(抗原) Mouse Nectin1 extracellular region (28-345 a.a.)-IgG-Fc fusion protein
交差性 [Gene ID]

Mouse[58235]

性状 1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C
標識 Unlabeled
メーカー MBL
別称 CD111, PRR, HIgR, HveC, PRR1, Pvrl1
背景 Nectins originally identified as poliovirus receptor-related protein (PRR) are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules. Nectins comprise a family of four members: nectin-1 (CD111/PRR1), nectin-2 (CD112/PRR2), nectin-3 (CD113/PRR3) and nectin-4 (PRR4). Nectin-2 and -3 are ubiquitously expressed whereas nectin-1 is abundantly expressed in brain, and nectin-4 is in placenta. Nectins colocalized with afadin, which an actin-filament binding protein to associated with the actin cytoskeleton. Nectins play important roles in diverse cell-cell junctions.
関連製品 D083-3 Anti-CD112 (Nectin-2) (Mouse) mAb
D175-3 Anti-CD112 (Human) mAb
製品カテゴリー 分野:神経科学 細胞膜表面抗原
データ

使用文献

Western Blotting

  1. Toyoshima D et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS One 9, e89763 (2014)(PMID:24587018)
  2. Maruo T et al. NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner. Genes Cells 22, 742-755 (2017)(PMID:28695613)

Immunocytochemistry

  1. Togashi H et al. Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol. 174, 141-51 (2006)(PMID:16801389)
  2. Ishiuchi T, Takeichi M. Nectins localize Willin to cell-cell junctions. Genes Cells. 17, 387-97 (2012)(PMID:22512338)

Immunohistochemistry

  1. Toyoshima D et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS One 9, e89763 (2014)(PMID:24587018)
  2. Geng X et al. Regulatory role of the cell adhesion molecule nectin‐1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus. Genes Cells. 21, 88-98 (2016)(PMID:26663531)
  3. Yoshida M et al. Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis. Genes Cells 17, 455-72 (2012)(PMID:22571182)
  4. Yoshida M et al. Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis. Genes Cells 17, 455-72 (2012)(PMID:22571182)
  5. Katsunuma S et al. Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium. J Cell Biol. 212, 561-75 (2016)(PMID:26929452)
  6. Maruo T et al. NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner. Genes Cells 22, 742-755 (2017)(PMID:28695613)

※在庫につきましては2019年09月22日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization

ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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