トップ > 製品検索結果一覧 > Code No. PD017 Anti-Beclin 1 pAb

Code No. PD017

Anti-Beclin 1 pAb

価格(税別)

¥38,000

在庫

10以上

(2019/06/16 00:05時点)

包装

100 µL

データ
  • Western Blotting

クローナリティー Polyclonal クローン Polyclonal
アイソタイプ
(免疫動物)
Rabbit Ig (aff.)
使用法
WB
1:1,000  
IP
2.5 μL/200 μL of cell extract from 5x106 cells  
IC
1:100  
IH*
reported  (PMID: 21490676
免疫原(抗原) Recombinant Human full length Beclin 1
交差性
[Gene ID]

Human[8678], Mouse[56208], Rat[114558], Hamster

性状 PBS/50% glycerol, pH 7.2
保存温度 -20°C 標識 Unlabeled メーカー MBL
別称 BECN1, ATG6, VPS30, beclin1
背景 Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Beclin 1, the mammalian homologue of yeast Atg6, was first identified Bcl-2-interacting protein. Beclin 1 localizes to the trans-Golgi network, and forms a complex with phosphatidylinositol 3-kinase. Beclin 1 is essential for early autophagosome formation.
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使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。

Western Blotting

  1. Matsunaga K et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol. 190, 511-21 (2010)(PMID:20713597)
  2. Russo R et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis. 2, e144 (2011)(PMID:21490676)
  3. Berliocchi L et al. Autophagy impairment in a mouse model of neuropathic pain. Mol Pain. 7, 83 (2011)Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013)(PMID:22023914)
  4. Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013)(PMID:23455425)
  5. Chen X et al. Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity. Protein Cell. 5, 912-27 (2014)(PMID:25311841)
  6. Liu ML et al. Tri-ortho-cresyl phosphate induces autophagy of rat spermatogonial stem cells. Reproduction. 149, 163-70 (2015)(PMID:25385720)
  7. Russo R et al. Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells. PLoS One. 9, e113682 (2014)(PMID:25419658)
  8. Munson MJ et al. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 34, 2272-90 (2015)(PMID:26139536)
  9. Lin SJ et al. Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline. Oncotarget. 6, 39329-41 (2015)(PMID:26513171)
  10. Fujiwara N et al. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem. 291, 10858-66 (2016)(PMID:26994142)
  11. Wei ZB et al. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. 12, 1168-79 (2016)(PMID:27171858)
  12. Liu X et al. Involvement of oxidative stress in tri-ortho-cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro. Reprod Biol Endocrinol. 14, 30 (2016)(PMID:27267904)
  13. Li S et al. Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells. Oncotarget. 7, 70364-70377 (2016)(PMID:27683118)
  14. Watanabe Y et al. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 7, 13508 (2016)(PMID:27869116)
  15. Wakatsuki S et al. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 216, 477-493 (2017)(PMID:28053206)
  16. An L et al. UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity. Sci Rep. 7, 43251 (2017)(PMID:28225086)
  17. Arasaki K et al. Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. Nat Commun. 8, 15406 (2017)(PMID:28504273)
  18. Zhao Z et al. Curcumin accelerates the repair of sciatic nerve injury in rats through reducing Schwann cells apoptosis and promoting myelinization. Biomed Pharmacother. 92, 1103-1110 (2017)(PMID:28622711)
  19. Fujiwara M et al. Decreased grip strength, muscle pain, and atrophy occur in rats following long-term exposure to excessive repetitive motion. FEBS Open Bio. 7, 1737-1749 (2017)(PMID:29123982)
  20. Han Y et al. Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid. Int J Mol Med. 41, 800-808 (2018)(PMID:29207032)
  21. Li M et al. Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. J Virol. 92, e02193-17 (2018)(PMID:29386287)
  22. Lin X et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 9, 768 (2018)(PMID:29991758)
  23. Zhang Yet al. TGF-β3 Promotes MUC5AC Hyper-Expression by Modulating Autophagy Pathway in Airway EBioMedicine. 33, 242-252 (2018)(PMID:29997053)
  24. Hagio-Izaki K et al. Lipopolysaccharide induces bacterial autophagy in epithelial keratinocytes of the gingival sulcus. BMC Cell Biol. 19, 18 (2018)(PMID:30165815)
  25. Jin GL et al. Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats. Front Pharmacol. 9, 989 (2018)(PMID:30214411)
  26. Wang M et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry (2018) In press(PMID:30531936)
  27. Sase K et al. Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage. Mol Med Rep. 18, 5455-5460 (2018) (PMID:30365082)

Immunoprecipitation

  1. Wei ZB et al. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. 12, 1168-79 (2016)(PMID:27171858)
  2. Wakatsuki S et al. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 216, 477-493 (2017)(PMID:28053206)
  3. Wang M et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry (2018) In press(PMID:30531936)

Immunohistochemistry

  1. Russo R et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis. 2, e144 (2011)(PMID:21490676)
  2. Sase K et al. Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage. Mol Med Rep. 18, 5455-5460 (2018) (PMID:30365082)
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※在庫につきましては2019年06月16日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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