Anti-rck (p54) pAb

価格（税別）

¥57,200

在庫

10以上

（2024/04/20 00:05時点）

包装

100 µL

使用文献

データシート

SDS

データ	Western Blotting Immunohistochemistry
クローナリティー	Polyclonal	クローン	Polyclonal
アイソタイプ（免疫動物）	Rabbit Ig (aff.)
使用法	WB 1:1,000 IC* reported. （PMID: 22674998 / 21109527 / 19812249） IH 1:100
免疫原(抗原)	synthetic peptide KLH-STARTENPVIC
交差性 [Gene ID]	Human[1656], Mouse[13209], Rat[500988], Monkey*(PMID: 19458173)
性状	1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度	-20°C	標識	Unlabeled	メーカー	MBL
別称	DDX6, HLR2
背景	The lymphoma-associated rck (p54) gene product is a member of the DEAD box protein/RNA helicase family which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. Overexpression of human rck in a guinea pig cell line strongly inhibited the cell growth, and rck (p54) overexpression was found in >65% of colorectal tumours and >90% of hepatocellular carcinomas. Expression in tumors highly correlates with c-myc expression (>92%), suggesting rck (p54) may contribute to cell proliferation and carcinogenesis by increasing synthesis of c-myc protein via increased translation initiation of c-myc mRNA.
関連製品	RN033P Anti-TNRC6A (GW182) (Human) pAb RN003M Anti-EIF2C2 (AGO2) (Human) mAb
使用文献	使用文献募集中！本製品を使って論文を発表されましたら是非お知らせください。 Western Blotting Llorens F et al. A highly expressed miR-101 isomiR is a functional silencing small RNA. BMC Genomics. 14, 104 (2013)(PMID:23414127) Pérez-Vilaró G et al. Hepatitis C virus infection alters P-body composition but is independent of P-body granules. J Virol. 86, 8740-9 (2012)(PMID:22674998) Melemedjian OK et al. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol. Pain 7, 70 (2011)(PMID:21936900) Yao B et al. Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acid Res. 39, 2534-47 (2011)(PMID:21131274) Broytman O et al. Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines. Neurobiol. Aging 30, 1962-74 (2009)(PMID:18378046) Pauley KM et al. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells. Immunol Cell Biol. 88, 205-12 (2010)(PMID:19918258) Lian S et al. Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol Cell Biol. 18, 3375-87 (2007)(PMID:17596515) Immunoprecipitation Yu SF et al. The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome. PLoS Pathog. 7, e1002303 (2011)(PMID:22022269) Immunocytochemistry Pérez-Vilaró G et al. Hepatitis C virus infection alters P-body composition but is independent of P-body granules. J Virol. 86, 8740-9 (2012)(PMID:22674998) Swetloff A et al. Dcp1-bodies in mouse oocytes. Mol Biol Cell. 20, 4951-61 (2009)(PMID:19812249) Carlos TS et al. Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells. J Gen Virol. 90, 2147-56 (2009)(PMID:19458173) Zeitelhofer M et al. Dynamic interaction between P-bodies and transport ribonucleoprotein particles in dendrites of mature hippocampal neurons. J Neurosci. 28, 7555-62 (2008)(PMID:18650333) Kino Y et al. Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acid Res. 39, 2781-98 (2011)(PMID:21109527) Moon SL, Parker R. Analysis of eIF2B bodies and their relationships with stress granules and P-bodies. Sci Rep. 8, 12264 (2018)(PMID:30115954)
製品カテゴリー	分野 RNA-RNPネットワークがん

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※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
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※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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