トップ > 製品検索結果一覧 > Code No. M162-3 Anti-p62 (SQSTM1) (Human) mAb

Code No. M162-3

Anti-p62 (SQSTM1) (Human) mAb

価格(税別)

¥48,000

在庫

10以上

(2017/09/21 01:30時点)

包装

100 µg/100 µL

データ
  • Western Blotting

  • Immunoprecipitation

  • Flow Cytometry

  • Immunocytochemistry

  • Immunohistochemistry

クローナリティー Monoclonal クローン 5F2
アイソタイプ
(免疫動物)
Mouse IgG1 κ
使用法
WB
1 µg/mL  
IP
2 µg/250 µL of cell extract from 2.5x106 cells  
FCM
2 µg/mL  
IC
5 µg/mL  
IH
2-10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
免疫原(抗原) Recombinant Human p62 (120-440 a.a.)
交差性
[Gene ID]

Human[8878], Mouse(-), Rat(-), Hamster(-)

性状 1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C 標識 Unlabeled メーカー MBL
別称 sequestosome 1, p60, p62, A170, OSIL, PDB3, ZIP3, p62B
背景 p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain. This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency.
関連製品 PM045 Anti-p62 (SQSTM1) pAb
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M162-A64 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor® 647
PM066 Anti-p62 C-terminal pAb
PM036 Anti-LC3 pAb
M152-3 Anti-LC3 mAb
M186-3 Anti-LC3 mAb
PD014 Anti-LC3 pAb
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PM072 Anti-VMP1 pAb
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PM090 Anti-Atg8 (Filamentous fungi) pAb
D343-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
D344-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
PM066-7 Anti-p62 C-terminal pAb-HRP-DirecT
PM074 Anti-Phospho-p62 (SQSTM1) (Ser351) pAb
M224-3 Anti-KEAP1 mAb
M200-3 Anti-NRF2 mAb
D343-3MS Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
D344-3MS Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
M152-3MS Anti-LC3 mAb for My select sampler set
PM066-7MS Anti-p62 C-terminal pAb-HRP-DirecT for My select sampler set
PM074MS Anti-Phospho-p62 (SQSTM1) (Ser351) pAb for My select sampler set
M230-3 Anti-Parkin mAb
M200-3MS Anti-NRF2 mAb for My select sampler set
PM037 Anti-GABARAP pAb
8486 Autophagy Watch
M135-3 Anti-GABARAP mAb
M217-3 Anti-Phospho-p62 (SQSTM1) (Ser351) mAb
M217-3MS Anti-Phospho-p62 (SQSTM1) (Ser351) mAb for My select sampler set
PM038 Anti-GATE-16 pAb
MK-12-3 Anti-Ubiquitin mAb
CY-7055 CycLex® Total p62 ELISA Kit
CY-7056 CycLex® Phospho-p62 Ser349 ELISA Kit
CY-7057 CycLex® Phospho-p62 Ser403 ELISA Kit
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。

Western Blotting

  1. Soll C et al. Serotonin promotes tumor growth in human hepatocellular cancer. Hepatology 51, 1244-54 (2010)(PMID:20099302)
  2. Fan W et al. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6, 614-21 (2010)(PMID:20495340)
  3. Wang BS et al. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 124, 203-14 (2013)(PMID:22963397)
  4. Rovetta F et al. ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Exp Cell Res. 318, 238-50 (2012)(PMID:22146761)
  5. Matsumoto G et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 44, 279-89 (2011)(PMID:22017874)
  6. Schmeisser H et al. Type I interferons induce autophagy in certain human cancer cell lines. Autophagy 9, 683-96 (2013)(PMID:23419269)
  7. Guo X et al. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death Dis. 4, e822 (2013)(PMID:24091665)
  8. Zhu X et al. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 125, 1098-110 (2015)(PMID:25642769)
  9. Janda E et al. Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection. Autophagy 11, 1063-80 (2015)(PMID:26046590)

Immunoprecipitation

  1. Wang BS et al. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 124, 203-14 (2013)(PMID:22963397)

Immunocytochemistry

  1. Akaishi R et al. Autophagy in the placenta of women with hypertensive disorders in pregnancy. Placenta 35, 974-80 (2014)(PMID:25465707)
  2. Janda E et al. Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection. Autophagy 11, 1063-80 (2015)(PMID:26046590)

Immunohistochemistry

  1. Wang BS et al. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 124, 203-14 (2013)(PMID:22963397)
  2. Park JM et al. Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther. 14, 100-7 (2013)(PMID:23192274)
  3. Onodera Y et al. NRF2 immunolocalization in human breast cancer patients as a prognostic factor. Endocr Relat Cancer. 21, 241-52 (2014)
  4. Akaishi R et al. Autophagy in the placenta of women with hypertensive disorders in pregnancy. Placenta 35, 974-80 (2014)(PMID:25465707)
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※在庫につきましては2017年09月21日 01時30分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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