| データ |
 Immunoprecipitation
Flow Cytometry
Immunohistochemistry
|
| クローナリティー |
Monoclonal
|
クローン |
mNI-11 |
アイソタイプ
（免疫動物）
|
Mouse IgG1
|
| 使用法 |
- IP
- 2 µg/400 µg of cell extract from 5x106 cells
- FCM
- 5 µg/mL (final concentration)
 - IH
- 10 µg/mL (Can be used in cryosections.)
- Co-IP*
- reported. （PMID: 29763414）
|
| 免疫原(抗原) |
LPS-stimulated U937
|
交差性
[Gene ID] |
Human[22918]
|
| 性状 |
1 mg/mL in PBS/50% glycerol, pH 7.2
|
| 保存温度 |
-20°C
|
標識 |
Unlabeled |
メーカー |
MBL |
| 別称 |
C1qRp
|
| 背景 |
CD93, also known as C1qRp, is a 100-125 kDa type I membrane protein that is a receptor for the complement protein C1q. CD93 has also been shown to act as a receptor for mannose-binding lectin and surfactant protein A. CD93 is expressed on the surface of monocytes, granulocytes, and endothelial cells, and expression is increased by TNF-α or GM-CSF. CD93 is involved in ligand-mediated enhancement of phagocytosis and intercellular adhesion.
|
| 関連製品 |
D198-5 Anti-CD93 (Human) mAb-PE
|
使用文献
|
使用文献募集中！本製品を使って論文を発表されましたら是非お知らせください。
Western Blotting - Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)
Co-IP - Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)
Flow Cytometry - McGreal EP et al. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol. 15, 5222-32 (2002)(PMID:11994479)
Immunocytochemistry - Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)
- Barbera S et al. The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration. Cell Commun Signal. 17, 55 (2019)(PMID:31138217)
|
| 参考文献 |
- Ikewaki N, Inoko H. Development and characterization of a novel monoclonal antibody (mNI-11) that induces cell adhesion of the LPS-stimulated human monocyte-like cell line U937. J Leukoc Biol. 59, 697-708 (1996)（PMID: 8656055）
- Ikewaki N et al. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells. J Clin immunol. 20, 317-24 (2000)（PMID: 10939719）
- McGreal EP et al. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol. 168, 5222-32 (2002)（PMID: 11994479）
- Ikewaki N et al. Regulation of CD93 cell surface expression by protein kinase C isoenzymes. Microbiol Immunol. 50, 93-103 (2006)（PMID: 16490927）
- Ikewaki N et al. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Microbiol Immunol. 51, 1189-200 (2007)（PMID: 18094537）
- Ikewaki N et al. Flow cytometric identification of CD93 expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood. J Clin Immunol.30, 723-33 (2010)（PMID: 20512406）
- Ikewaki N et al. Unique properties of cluster of differentiation 93 in the umbilical cord blood of neonates. Microbiol Immunol. 57, 822-32 (2013)（PMID: 24033555）
- Ikewaki N et al. Serum levels of soluble CD93 in patients with chronic renal failure. J. of Kyushu Univ. of Health and Welfare 17, 81-8 (2016)
- Nativel B et al. CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA. Immunology. 158, 85-93 (2019)（PMID: 31335975）
|
製品
カテゴリー |
- 分野
- 細胞膜表面抗原
|
使用文献
データシート